C-ANCA (cytoplasmic antineutrophil cytoplasmic antibody) test

The C-ANCA (cytoplasmic antineutrophil cytoplasmic antibody) test is a blood test that detects the presence of specific autoantibodies called PR3-ANCA, which target proteinase 3 (PR3) in the neutrophils’ cytoplasm. These antibodies are associated with autoimmune vasculitis, such as granulomatosis with polyangiitis (GPA) and other ANCA-associated vasculitides[1].

Indications of the Test

The C-ANCA test is used to diagnose and monitor autoimmune vasculitis conditions, including granulomatosis with polyangiitis. It helps in the evaluation of patients with suspected vasculitis and in assessing disease activity[2].

Patient Preparation/Instructions

No special preparation is usually required for the C-ANCA test. However, it is essential to follow any specific instructions provided by the healthcare provider or the testing facility.

Typical Reference Values:

The interpretation of C-ANCA test results is based on the antibody titer. In patients with active systemic disease, elevated C-ANCA titers are over 98% sensitive and specific for GPA. The reference range for C-ANCA testing is typically provided as the titer of the antibody, and the results are interpreted based on the specific laboratory’s reference values[3].

Turnaround Time:

The turnaround time for the C-ANCA test may vary depending on the testing facility. Typically, results are available within a few days to a week after the blood sample is collected.

Order This Test:

You can order the C-ANCA test by clicking the “Order Test” button and adding it to your cart. Once the test is added to the cart, you can proceed to checkout for the payment and schedule the blood sample collection.

References:
[1] c-ANCA – Wikipedia https://en.wikipedia.org/wiki/C-ANCA
[2] Antineutrophil Cytoplasmic Antibodies (ANCA) Test: MedlinePlus Medical Test https://medlineplus.gov/lab-tests/antineutrophil-cytoplasmic-antibodies-anca-test/
[3] Antineutrophil Cytoplasmic Autoantibody, Cytoplasmic (c-ANCA): Reference Range, Interpretation, Collection and Panels https://emedicine.medscape.com/article/2086572-overview
[4] ANCA Positive Vasculitis https://www.ncbi.nlm.nih.gov/books/NBK554372/
[5] C-ANCA – an overview | ScienceDirect Topics https://www.sciencedirect.com/topics/medicine-and-dentistry/c-anca