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Gastric Parietal Cell Antibody Test, Serum


Test Description

The Gastric Parietal Cell Antibody Test, also known as the Anti-gastric Parietal Cell Antibody (GPC test), is a blood test that detects the presence of antibodies against gastric parietal cells. These antibodies are associated with autoimmune conditions such as autoimmune atrophic gastritis (AAG) and pernicious anemia (PA)[1].

The gastric parietal cells secrete intrinsic factor (IF) that binds Vitamin B12 and aids in its abosrption from the GI tract.

Indications of the  GPC Test

The test is used to screen for autoimmune atrophic gastritis and pernicious anemia. Antibodies to gastric parietal cells are necessary for the absorption of vitamin B12, essential for erythropoiesis. The destruction of these cells can lead to vitamin B12 deficiency and anemia[1].

Patient Preparation/Instructions

No special preparation is usually needed for this test. However, it’s essential to follow any instructions provided by the healthcare provider or the testing facility.

Typical Reference Values for GPC Test

A normal result is called a negative result, indicating the absence of antibodies against gastric parietal cells. The specific reference values may vary slightly among different laboratories[2].

Turnaround Time

The test results are typically available within 2 to 4 days[5].

Order The GPC Test

You can order this test by clicking the “Order Test” button and adding it to your cart. After placing the order, you will be guided through the necessary steps to complete the process.


[1] Anti-gastric parietal cell antibody (GPC) – South Tees Hospitals NHS Foundation Trust https://www.southtees.nhs.uk/services/pathology/tests/anti-gastric-parietal-cell-antibody-gpc/
[2] Antiparietal cell antibody test https://www.mountsinai.org/health-library/tests/antiparietal-cell-antibody-test
[3] Anti-parietal cell antibodies – diagnostic significance – PubMed https://pubmed.ncbi.nlm.nih.gov/26918709/
[4] Parietal Cell Antibody – an overview | ScienceDirect Topics https://www.sciencedirect.com/topics/medicine-and-dentistry/parietal-cell-antibody
[5] Test ID: PCAB Parietal Cell Antibodies, IgG, Serum https://neurology.testcatalog.org/show/PCAB

By Perplexity at https://www.perplexity.ai/search/2595a46c-0308-4dec-b878-5602e6eee72a?s=m

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