The SLE Profile is a comprehensive blood test used to detect autoantibodies commonly found in individuals with Systemic Lupus Erythematosus (SLE), a chronic autoimmune disease in which the immune system mistakenly attacks healthy tissues. The test is based on the following markers such as antinuclear antibodies (ANA), anti-double-stranded DNA (anti-dsDNA), anti-Smith (Sm) antibodies, and complement proteins (C3 and C4) in identifying immune system abnormalities and assessing disease activity.
Indications of the Test
You may consider taking the SLE Profile if you:
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Are experiencing symptoms like fatigue, joint pain, rashes, or persistent low-grade fever
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Have signs of organ involvement such as kidney issues (e.g., blood or protein in urine)
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Have a family history of autoimmune diseases
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Need to monitor an existing diagnosis of SLE or assess treatment response
Patient Preparation / Instructions
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No fasting is required.
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Wear a short-sleeved shirt to make blood collection easier.
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Let your healthcare provider know about any medications, symptoms, or past autoimmune diagnoses.
Typical Reference Values
While exact ranges may vary by lab, here are general reference values:
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ANA: Negative (<1:40)
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Anti-dsDNA: Negative (<10 IU/mL)
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C3: 90–180 mg/dL
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C4: 10–40 mg/dL
Your test results will be interpreted alongside your symptoms and other clinical findings.
Interpretation
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Positive ANA with specific antibodies (anti-dsDNA, anti-Sm) supports a diagnosis of SLE.
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Low complement levels (C3, C4) may suggest active disease or lupus nephritis.
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Urinalysis results can point to kidney involvement, often requiring further evaluation.
Interpretation will be clearly explained in your report. If necessary, your doctor may recommend additional tests or referral to a rheumatologist.
Turnaround Time
Results are usually available within 1 to 3 Workings Hour after your sample is collected.
Order Systemic Lupus Erythematosus (SLE) Profile
If you suspect lupus or have been experiencing persistent unexplained symptoms, consider ordering the Systemic Lupus Erythematosus (SLE) Profile today. Please click the ‘Order Test’ button and put the Systemic Lupus Erythematosus (SLE) Profile in your cart. You are welcome to visit our laboratory in Kilimani, Nairobi.
This will initiate the process for obtaining your test
