The Yo Neuronal Antibody Test is a specialized blood or cerebrospinal fluid (CSF) test that detects anti-Yo antibodies also known as Purkinje cell cytoplasmic antibody type 1 (PCA-1). These autoantibodies are strongly linked to paraneoplastic cerebellar degeneration (PCD), a rare neurological disorder caused by an immune response to certain cancers, most commonly ovarian or breast cancer.
Indications for the Test
The Yo Neuronal Antibody Test is recommended for individuals who:
Experience sudden or rapidly worsening balance issues or ataxia
Show signs of slurred speech, unsteady gait, or involuntary eye movements
Have been diagnosed with breast, ovarian, or lung cancer and now present with neurological symptoms
Are being evaluated for a paraneoplastic neurological syndrome
Patient Preparation
The test involving blood sample Blood:
No fasting required
A standard blood draw is performed from your arm
CSF analysis (lumbar puncture):
May require fasting for 4–6 hours
Discontinue blood thinners (as advised by your doctor)
Empty bladder before the procedure
Plan for rest after the test to reduce the risk of headache
Always inform your healthcare provider about any medications or medical conditions prior to the test.
Reference Values
Negative: No anti-Yo antibodies detected
Positive: Presence of anti-Yo antibodies, suggesting high likelihood of paraneoplastic cerebellar degeneration.
Interpretation of Results
Positive Result:
Strongly suggests an autoimmune neurological condition like PCD
Commonly associated with ovarian, breast, or lung cancer
Should prompt comprehensive cancer screening and specialist follow-up
Negative Result:
Does not completely exclude paraneoplastic syndromes
Further testing for other antibodies or imaging studies may be necessary
Turnaround Time
Test results are usually available within 3 to 14 days, depending on whether testing is done locally or sent to a specialized reference laboratory.
Order Yo Neuronal Antibody Test in Kenya
To request the Yo Neuronal Antibody Test, click the ‘Order Test’ button and add the test to your cart.
Alternatively, visit our laboratory in Kilimani, Nairobi. to initiate the testing process.