Cryptococcus Indian Ink, CSF

Test Description

Cryptococcus Indian Ink, CSF is a diagnostic test used to detect the presence of Cryptococcus neoformans in cerebrospinal fluid (CSF) specimens. The test employs a modified India ink technique that allows for the clear identification of some external and internal structures of the organism. Cryptococcus neoformans is an encapsulated yeast that can cause meningitis, particularly in immunocompromised individuals, such as those with acquired immunodeficiency syndrome (AIDS).

Indications of the Test

The Cryptococcus Indian Ink, CSF test is indicated for patients suspected of having Cryptococcus neoformans meningitis. The classic India ink test is positive in only half of cryptococcal meningitis cases, and reliable, rapid cryptococcal antigen (CRAG) testing requires technical expertise and facilities not always available. Therefore, microscopic examination of CSF sediment using May-Giemsa, periodic acid-Schiff, and Gram stains is used in conjunction with the India ink test to increase the sensitivity of the diagnosis.

Patient Preparation/Instructions

No special patient preparation is required for the Cryptococcus Indian Ink, CSF test.

Typical Reference Values

The Cryptococcus Indian Ink, CSF test is qualitative and is reported as positive or negative for the presence of Cryptococcus neoformans in the CSF specimen.

Turnaround Time

The turnaround time for the Cryptococcus Indian Ink, CSF test is typically 24-48 hours.

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