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Test Description
The Tobramycin Levels Test measures the levels of tobramycin in the blood, a powerful antibiotic used to treat various bacterial infections, including those caused by Pseudomonas aeruginosa. It is often used in combination with beta-lactam therapy[1].
Indications of the Test
The test is used to monitor the adequacy of serum concentration during tobramycin therapy, particularly in cases of prolonged use. It is also helpful in detecting potential toxicity, such as ototoxicity and nephrotoxicity[1][4].
Patient Preparation/Instructions
There are no specific instructions for patient preparation. However, it is essential to inform the healthcare provider about any medications being taken, as the risk of toxicity is enhanced in the presence of other ototoxic or nephrotoxic drugs[4].
Typical Reference Values
– Therapeutic peak: 6.0-10.0 μg/mL
– Therapeutic trough: 0.5-1.5 μg/mL[1]
Turnaround Time
The turnaround time for this test is typically 72 hours[2].
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References
[1] Tobramycin, Serum, Peak https://www.labcorp.com/tests/007154/tobramycin-serum-peak[2] Tobramycin Blood Levels after Local Antibiotic Treatment of Bone and Soft Tissue Infection – PubMed https://pubmed.ncbi.nlm.nih.gov/35326799/
[3] Presence of tobramycin in blood and urine during selective decontamination of the digestive tract in critically ill patients, a prospective cohort study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334791/
[4] TOBRA – Overview: Tobramycin, Random, Serum https://www.mayocliniclabs.com/test-catalog/overview/37065
[5] Tobramycin (Inhalation Route) https://www.mayoclinic.org/drugs-supplements/tobramycin-inhalation-route/side-effects/drg-20072503
By Perplexity at https://www.perplexity.ai/search/1e4b1b58-e5b4-49a1-bfa4-3df05d8dec9f?s=m
