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Triple Screen for Down Syndrome



Triple Screen for Down Syndrome

The Triple Screen for Down syndrome is a blood test conducted during the second trimester of pregnancy to estimate the risk of Down syndrome and other genetic disorders in a fetus. It measures the levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated estriol in the mother’s blood. The test results, combined with the mother’s age, weight, ethnicity, and gestation of pregnancy, help assess the probabilities of potential genetic disorders.

Indications of the Test

The Triple Screen is recommended for women who:

  • Have a family history of birth defects
  • Are 35 years or older
  • Used possible harmful medications or drugs during pregnancy
  • Have diabetes and use insulin
  • Had a viral infection during pregnancy
  • Have been exposed to high levels of radiation

Patient Preparation/Instructions

There is no specific preparation required for the Triple Screen test. However, it is essential to inform the healthcare provider of any medications, supplements, or medications being taken during pregnancy, as some may interfere with the test results.

Typical Reference Values

The Triple Screen test has a sensitivity of 70% and a false-positive rate of 5%. It can detect an increased risk of Down syndrome, trisomy 18, open neural tube defects, Turner syndrome, triploidy, trisomy 16 mosaicism, fetal death, Smith–Lemli–Opitz syndrome, and steroid sulfatase deficiency.

Turn Around Time

The turn around time for the Triple Screen test is typically 1-2 weeks.

Order This Test

To order the Triple Screen test, click the ‘Order Test’ button and add it to your cart.

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